Aptamers—synthetic DNA or RNA molecules that bind to target molecules—can be used to test for foodborne bacterial pathogens, though their specificity (the probability of returning a negative result in the absence of the focal pathogen) in real-world foods has been unclear. Sandeep Somvanshi et al. fabricated test paper incorporating aptamers targeting strain O157:H7 of the bacteria Escherichia coli; the paper shifts from pink to purple as the aptamers bind to target molecules. Somvanshi et al. tested the paper in store-bought pear juice they treated with E. coli O157:H7, other strains of E. coli, or other bacteria species. Following exposure, the paper from the O157:H7 test was purple while papers from the other tests were pink, suggesting that blank
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